Recognizing the rising importance of neglected and underutilized species, in 2016 ANAFE convened workshops of agricultural educators in Africa who endorsed the ideas of developing a curriculum on NUS to fill the yawning knowledge and expertise gap. ANAFE supported the curriculum development process and the first NUS curriculum was produced and is being adopted by many colleges and universities in Africa. However, educators are searching for suitable learning resources to use in the teaching processes. This learning manual is the first such resource developed by ANAFE, thanks to support from Fondazione Edu an Italian partner. The learning resources cover very few crop and animal species. ANAFE organized this manual using experts from colleges and universities in Africa, who collaboratively shared resources available in reports, research papers, internet etc. to compile credible knowledge.